Nerve growth factor (NGF)-stimulated neurite outgrowth in the rat PC12 tumor cell line recently has been shown to depend on the activation of the mitogen-activated protein (MAP) kinase kinase 1 (MEK1) (Pang et al.: J Biol Chem 270:13585-13588,1995). In this study we have analyzed whether or not func
Comparative analysis of brain neurite-stimulating protein and nerve growth factor using a culture of chick embryo sensory neurons
โ Scribed by V. P. Goncharova; G. N. Akoev; A. V. Romanyuk; N. I. Chalisova
- Book ID
- 112711604
- Publisher
- Springer US
- Year
- 1988
- Tongue
- English
- Weight
- 373 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0090-2977
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We used compartmented cultures into NGF plus NT3 compartments, while the combinato study the regulation of adult sensory neurite growth tion of BDNF plus NGF resulted in an inhibition of by neurotrophins. We examined the effects of the neuneurite extension compared with NGF alone. We then rotrophins
## Abstract Although neurons of the PNS no longer require neurotrophins such as Nerve Growth Factor (NGF) for their survival, such factors are involved in regulating axonal sprouting and regeneration after injury. In addition to the neurotrophin receptors, sensory neurons are reported to express IG