𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Common or Rare Variants for Complex Traits?

✍ Scribed by Munafò, Marcus R.; Flint, Jonathan

Book ID
122282769
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
141 KB
Volume
75
Category
Article
ISSN
0006-3223

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Detecting rare variants for complex trai
Detecting rare variants for complex traits using family and unrelated data
✍ Xiaofeng Zhu; Tao Feng; Yali Li; Qing Lu; Robert C. Elston 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 321 KB

## Abstract Large genome‐wide association studies (GWAS) have been performed to detect common genetic variants involved in common diseases, but most of the variants found this way account for only a small portion of the trait variance. Furthermore, candidate gene‐based resequencing suggests that ma

Detecting rare and common variants for c
Detecting rare and common variants for complex traits: sibpair and odds ratio weighted sum statistics (SPWSS, ORWSS)
✍ Tao Feng; Robert C. Elston; Xiaofeng Zhu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB

It is generally known that risk variants segregate together with a disease within families, but this information has not been used in the existing statistical methods for detecting rare variants. Here we introduce two weighted sum statistics that can apply to either genome-wide association data or r

Optimum designs for next-generation sequ
Optimum designs for next-generation sequencing to discover rare variants for common complex disease
✍ Gang Shi; D.C. Rao 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB

Recent advances in next-generation sequencing technologies make it affordable to search for rare and functional variants for common complex diseases systematically. We investigated strategies for enriching rare variants in the samples selected for sequencing so as to optimize the power for their dis