✦ LIBER ✦

Common mechanisms for the control of eukaryotic transcriptional elongation

✍ Scribed by Anton Krumm; Tea Meulia; Mark Groudine

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 942 KB
Volume: 15
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950151005

No coin nor oath required. For personal study only.

✦ Synopsis

Regulation of transcriptional elongation is emerging as an important control mechanism for eukaryotic gene expression. In this essay, we review the basis of the current view of the regulation of elongation in the human cmyc gene and discuss similarities in elongation control among the c-myc, Drosophila hsp70 and the HIV-1 genes. Based upon these similarities, we propose a model for control of expression of these genes at the elongation phase of transcription. This model suggests that distinct promoter elements direct the assembly of RNA polymerase I1 transcription complexes which differ in their elongation efficiency.

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