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Common and reversible regulation of wild-type p53 function and of ribosomal biogenesis by protein kinases in human cells

✍ Scribed by David-Pfeuty, Thérèse; Nouvian-Dooghe, Yolande; Sirri, Valentina; Roussel, Pascal; Hernandez-Verdun, Danièle


Book ID
110065985
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
601 KB
Volume
20
Category
Article
ISSN
0950-9232

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A puzzling finding in various human tumors, including glioblastoma multiforme (GBM), is the stabilization of wildtype (wt) p53 protein. The biological significance of this phenomenon and the mechanism by which it occurs are unexplained. Recent reports have revealed that mdm2 exerts its negative regu