Comment on ‘Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy’
✍ Scribed by Timothy L. Lash; Thomas P. Ahern; Deirdre Cronin-Fenton; Jens Peter Garne; Stephen Hamilton-Dutoit; Henrik Toft Sørensen
- Book ID
- 108584246
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 56 KB
- Volume
- 99
- Category
- Article
- ISSN
- 1347-9032
No coin nor oath required. For personal study only.
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## Abstract ## BACKGROUND Current adjuvant hormone therapy in postmenopausal women with breast cancer is debatable between upfront aromatase inhibitors (AIs) and sequential treatment with tamoxifen. A major concern is the higher rate of early recurrences observed with sequential treatment. The aut
The study by Okishiro et al 1 concludes that the cytochrome P450 (CYP) genotype CYP2D6\*10/\*10 is unlikely to have a clinically significant impact on prognosis in women with breast cancer who receive adjuvant tamoxifen. However, several aspects of the study by Okishiro et al call their conclusions