𝔖 Bobbio Scriptorium
✦   LIBER   ✦

CoMFA Modeling of Human Catechol O-Methyltransferase Enzyme Kinetics.

✍ Scribed by Julius Sipilae; Jyrki Taskinen

Publisher
John Wiley and Sons
Year
2004
Weight
51 KB
Volume
35
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Validation of assay of catechol-O-methyl
Validation of assay of catechol-O-methyltransferase activity in human erythrocytes
✍ Päivi Tuomainen; Ilkka Reenilä; Pekka T. Männistö 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 570 KB

The multistep assay of specific catechol-O-methyltransferase (COMT) activity in human erythrocytes was validated. Enzyme preparations from lysed erythrocytes were incubated with a substrate (3,4-dihydroxybenzoic acid) in the presence of Mg2+ and S-adenosylmethionine. The reaction products (vanillic

Expression of multiple catechol-o-methyl
Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain
✍ Elizabeth M. Tunbridge; Tracy A. Lane; Paul J. Harrison 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB

## Abstract Catechol‐o‐methyltransferase (COMT) is important for modulating dopamine levels, prefrontal cortex (PFC) function, and several psychiatric phenotypes. A single COMT mRNA has been described in human brain, which gives rise to membrane‐bound (MB)‐ and soluble (S)‐COMT proteins. In additio

Assessment of catechol-O-methyltransfera
Assessment of catechol-O-methyltransferase activity and its inhibition in erythrocytes of animals and humans
✍ Gerhard Zürcher; Mosé Da Prada; Jasper Dingemanse 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 475 KB

A non-radiometric method to measure the catechol-0-methyltransferase (COMT) activity in erythrocytes was modified to increase its sensitivity four-fold as well as its reproducibility and applicability. The method is based on the COhlT-mediated O-methyiation of 44naphtho [1,2-d] thiazol-2-yl) pyrocat