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CoMFA and Docking Studies on Glycogen Phosphorylase a Inhibitors as Antidiabetic Agents#

โœ Scribed by Prathipati, Philip; Pandey, Gyanendra; Saxena, Anil K.


Book ID
111929454
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
286 KB
Volume
45
Category
Article
ISSN
0095-2338

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In this study, comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were performed on a series of 2-substituted 5-hydroxyindole-3-carboxylate derivatives as potent 5-LOX inhibitors with IC(50) values ranging from 0.031 to 13.4 ฮผM. Two datasets o