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Docking, CoMFA and CoMSIA studies of a series of sulfonamides derivatives as carbonic anhydrase I inhibitors

✍ Scribed by Ghasemi, Jahan B.; Meftahi, Nastaran


Book ID
120482329
Publisher
Informa plc
Year
2011
Tongue
English
Weight
863 KB
Volume
28
Category
Article
ISSN
1475-6366

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In this study, comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were performed on a series of 2-substituted 5-hydroxyindole-3-carboxylate derivatives as potent 5-LOX inhibitors with IC(50) values ranging from 0.031 to 13.4 ΞΌM. Two datasets o