CoMFA and CoMSIA studies on 5-hydroxyind
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P. Aparoy; G.K. Suresh; K. Kumar Reddy; P. Reddanna
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Article
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2011
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Elsevier Science
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English
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In this study, comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were performed on a series of 2-substituted 5-hydroxyindole-3-carboxylate derivatives as potent 5-LOX inhibitors with IC(50) values ranging from 0.031 to 13.4 ΞΌM. Two datasets o