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Combining several polymorphisms of thymidylate synthase gene for pharmacogenetic analysis

✍ Scribed by Krajinovic, M; Costea, I; Primeau, M; Dulucq, S; Moghrabi, A


Book ID
110075408
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
114 KB
Volume
5
Category
Article
ISSN
1470-269X

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has