## Abstract The core histones are the primary protein component of chromatin, which is responsible for the packaging of eukaryotic DNA. The NH~2~โterminal tail domains of the core histones are the sites of numerous postโtranslational modifications that have been shown to play an important role in t
Combining Mass Spectrometry and Peptide Arrays to Profile the Specificities of Histone Deacetylases
โ Scribed by Zachary A. Gurard-Levin; Joohoon Kim; Milan Mrksich
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 588 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1439-4227
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## Abstract Qualitative and quantitative analysis of postโtranslational protein modifications by mass spectrometry is often hampered by changes in the ionization/detection efficiencies caused by amino acid modifications. This paper reports a comprehensive study of the influence of phosphorylation a