Combined VM-26 and cytosine arabinoside in treatment of refractory childhood lymphocytic leukemia
β Scribed by Gaston Rivera; Rhomes J. Aur; Gary V. Dahl; Charles B. Pratt; Adynel Wood; Thomas L. Avery
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 520 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0008-543X
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## Abstract Eleven patients with acute lymphocytic leukemia in relapse were treated with Lβasparaginase and cytosine arabinoside (1βΞ²βDβarabinofuranosylcytosine) in induction therapy and the same drugs plus cyclophosphamide in maintenance therapy. Three patients had complete remissions lasting 6, 1
Twenty-five adult patients with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. Overall, nine patients (36%) achieved complete