Thirteen leukemic patients with disease refractory to conventional chemotherapy were treated with 1.0 to 7.5 g/m2 of Cytosine Arabinoside (Ara-C) over 29 drug cycles. Drug infusions were spaced at 12-hour intervals; a maximum of four doses was administered over 36 hours. After single dose tolerance
Cytosine arabinoside and 6-thioguanine in refractory acute lymphocytic leukemia
โ Scribed by Dr. J. Hugh Bryan; Edward S. Henderson; Brigid G. Leventhal
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 478 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0008-543X
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Eighteen children with acute myeloid leukemia have been treated with a fourdrug protocol using cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine. The initial remission rate overall was 78%. Of 15 children who completed a week's treatment, i.e. one complete cycle, 14