✦ LIBER ✦

Combined role of tumor angiogenesis, bcl-2, and p53 expression in the prognosis of patients with colorectal carcinoma

✍ Scribed by Alexandra Giatromanolaki; George P. Stathopoulos; Eleni Tsiobanou; Costandina Papadimitriou; Vassilios Georgoulias; Kevin C. Gatter; Adrian L. Harris; Michael I. Koukourakis

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 634 KB
Volume: 86
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19991015)86:8<1421::aid-cncr6>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND. The objective of this study was to evaluate intratumoral neoangiogenesis in Dukes Stage B and Stage C (AJCC/UICC Stage I and III) colorectal adenocarcinoma and its correlation with nuclear p53 oncoprotein accumulation and cytoplasmic bcl-2 expression as well as to assess the prognostic significance of these features in patient outcome. METHODS. Paraffin embedded specimens from 55 patients with Dukes Stage B (AJCC/UICC Stage I) and 51 patients with Dukes Stage C (AJCC/UICC Stage III) colorectal adenocarcinoma who were treated with surgery were assessed. Patients with lymph node involvement (Dukes Stage C [AJCC/UICC Stage III]) also were treated with postoperative pelvic radiotherapy and adjuvant chemotherapy with 5-fluorouracil and leucovorin with or without interferon-␣. Immunohistochemistry was performed using the anti-CD31 monoclonal antibody (MoAb) for vessel staining, the DO7 MoAb for nuclear p53 expression, and the clone 124 for cytoplasmic/ perinuclear bcl-2 expression. Patient follow-up ranged from 4 -70 months (median, 28 months).

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