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Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells

✍ Scribed by Joshua Bliesath; Nanni Huser; Mayuko Omori; Daniel Bunag; Chris Proffitt; Nicole Streiner; Caroline Ho; Adam Siddiqui-Jain; Sean E. O’Brien; John K.C. Lim; David M. Ryckman; Kenna Anderes; William G. Rice; Denis Drygin


Book ID
116335880
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
787 KB
Volume
322
Category
Article
ISSN
0304-3835

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This study found that phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling was activated in human T-cell lymphotropic virus type I (HTLV-1)-infected leukemia cells. Rapamycin (1-100 nM, 48 h), the inhibitor of mTOR and its analog RAD001 (1-100 nM, 48 h)-induced gro