## Abstract ## Background Viruses are being exploited as vectors to deliver therapeutic genetic information into target cells. The success of this approach will depend on the ability to overcome current limitations, especially in terms of safety and efficiency, through molecular engineering of the
Combined effects of adeno-associated virus vector and a herpes simplex virus mutant as neoplastic therapy
β Scribed by Hideki Kasuya; Masaaki Mizuno; Jun Yoshida; Yukihiro Nishiyama; Shuji Nomoto; Akimasa Nakao
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 741 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## Background The development of stable producer cell lines for recombinant adenoβassociated virus (rAAV) assembly is a strategy followed by many groups to develop scalable production methods suitable for good manufacturing practice (GMP) requirements. The major drawback of this method
inhibitors of the ribonucleotide reductase of herpes simplex viruses (HSV) potentiate the activity of acyclovir in vitro and in animal studies. In addition, the combination of the ribonucleotide reductase inhibitor 348U87 and acyclovir has synergistic therapeutic effects against infections in mice d