Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma
โ Scribed by Q.-L. Fu; X. Li; H.K. Yip; Z. Shao; W. Wu; S. Mi; K.-F. So
- Book ID
- 116788967
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 896 KB
- Volume
- 162
- Category
- Article
- ISSN
- 0306-4522
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Adult rat retinal ganglion cells (RGC) undergo degeneration after optic nerve transection. Studies have shown that exogenously applied neurotrophic factors such as brain-derived neurotrophic factor (BDNF) can attenuate axotomy-induced as well as developmental RGC death. Here, we examined whether gli
## Abstract Application of basic fibroblast growth factor (FGFโ2) to the optic nerve after axotomy promotes the survival of retinal ganglion cells (RGCs) in the frog __Rana pipiens__ and results in a rapid upโregulation of brainโderived neurotrophic factor (BDNF) and TrkB synthesis by the RGCs. Her