Combination Brain-Derived Neurotrophic Factor and LINGO-1 Fusion Protein Promote Long-Term Survival to Retinal Ganglion Cells after Ocular Hypertension
โ Scribed by Fu, Qing-Ling; Yip, Henry K.; Li, Xin; Shao, Zhaohui; Wu, Wutian; Mi, Sha; So, Kwok-Fai
- Book ID
- 123028622
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 99 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0168-0102
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Adult rat retinal ganglion cells (RGC) undergo degeneration after optic nerve transection. Studies have shown that exogenously applied neurotrophic factors such as brain-derived neurotrophic factor (BDNF) can attenuate axotomy-induced as well as developmental RGC death. Here, we examined whether gli
## Abstract Application of basic fibroblast growth factor (FGFโ2) to the optic nerve after axotomy promotes the survival of retinal ganglion cells (RGCs) in the frog __Rana pipiens__ and results in a rapid upโregulation of brainโderived neurotrophic factor (BDNF) and TrkB synthesis by the RGCs. Her