Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line
β Scribed by Shashi Mehta; Dilshad Blackinton; Imran Omar; Nicola Kouttab; Dorkina Myrick; Shashi Mehta; Dorkina Myrick; Jim Klostergaard; Harold Wanebo
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 205 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## Background Human papillomavirus (HPV)βpositive cases of squamous cell carcinoma of the head and neck (SCCHN) have a much better disease outcome compared to SCCHN cases lacking HPV. Differences in microRNA (miRNA) expression may affect their clinical outcomes. ## Methods The miRNA
Abnormalities in the p53 gene were studied in a series of cell lines of human squamous-cell carcinoma of the head and neck (SCCHN) and in tumor tissues. Restriction-fragment-length polymorphism (RFLP), quantitative hybridization and immunochemical analysis of mutant p53 proteins were combined to det