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Combinatorial synthesis of novel thiourea derivatives on a modified poly(ethylene glycol)

✍ Scribed by Gui-Chun Yang; Zu-Xing Chen; Zhao-Jun Zhang

Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
220 KB
Volume
51
Category
Article
ISSN
1381-5148

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✦ Synopsis

A modified poly(ethylene glycol) (PEG) has been developed for the soluble polymer-supported combinatorial synthesis of novel thiourea derivatives. Dihydroxy-PEG with an average MW of 4000 was used as soluble polymer supports, a benzoyl residue as spacer, and 4-oxybenzoyl chloride group as the moiety with the reactive functionality. Representative thiourea derivatives were obtained in moderate to high yields with excellent purity from these modified PEG-bound products by cleavage with 6% ammonium water. In each step of the sequence, the PEG-bound products were precipitated in cold Et O 2 and the excessive reagents and by-products were removed by simple filtration. The progress of reaction, purities of the 1 isolation and the configuration of the PEG-bound products were easily monitored by TLC, IR and H NMR

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