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Combinatorial regulation of the murine RAG-2 promoter by Sp1 and distinct lymphocyte-specific transcription factors

✍ Scribed by Gustavo A. Miranda; Maria Villalvazo; Zoran Galic; Jackelyn Alva; Roxanna Abrines; Yvette Yates; Cory J. Evans; Renato J. Aguilera


Book ID
117325402
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
342 KB
Volume
38
Category
Article
ISSN
0161-5890

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✍ Alia Al-Sarraj; Regina M. Day; Gerald Thiel 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB

## Abstract The transcription factors Sp1, Sp3, and Egr‐1 bind with their zinc finger DNA‐binding domains to GC‐rich sequences in the regulatory regions of their target genes. The similarity of the DNA‐binding sites of Sp1, Sp3, and Egr‐1 has triggered the hypothesis that they compete for the same