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Combinatorial Pharmacologic Effects of Gemcitabine and its Metabolite dFdU

✍ Scribed by Prof. Alexey Benyumov; Prof. Vadim J. Gurvich; Dr. Lev G. Lis; Brent W. Williams; Prof. Mark N. Kirstein


Book ID
102804359
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
559 KB
Volume
6
Category
Article
ISSN
1860-7179

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Simultaneous determination of gemcitabin
✍ Elena Marangon; Federica Sala; Orazio Caffo; Enzo Galligioni; Maurizio D'Incalci πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 420 KB πŸ‘ 1 views

## Abstract Gemcitabine, 2β€²,2′‐difluoro‐2′‐deoxycytidine (dFdC) is a pyrimidine antimetabolite employed against several human malignancies. It undergoes intracellular activation to the pharmacologically active triphosphate form (dFdCTP) and metabolic inactivation to the metabolite 2β€²,2′‐difluorodeo