✦ LIBER ✦

Combinatorial modification of 2-ketopiperazine with solid phase C-alkylation and N-acylations

✍ Scribed by Zhaoning Zhu; Brian Mckittrick

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 181 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01675-x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Solid-phase synthesis and screening of N

Solid-phase synthesis and screening of N-acylated polyamine (NAPA) combinatorial libraries for protein binding

✍ Jaclyn A. Iera; Lisa M. Miller Jenkins; Hiroshi Kajiyama; Jeffrey B. Kopp; Danie 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 496 KB

Inhibitors for protein-protein interactions are challenging to design, in part due to the unique and complex architectures of each protein's interaction domain. Most approaches to develop inhibitors for these interactions rely on rational design, which requires prior structural knowledge of the targ

Parallel solid phase synthesis of tetras

Parallel solid phase synthesis of tetrasubstituted diethylenetriamines via selective amide alkylation and exhaustive reduction of N-acylated dipeptides

✍ Adel Nefzi; John M. Ostresh; Richard A. Houghten 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 441 KB

Polyamines are a rapidly developing area of vital importance to biomedical science. Selective N-alkylation followed by N-terminal acylation and the complete reduction of carbonyl amide bonds enables the preparation by parallel solid phase synthesis of a wide range of N ~,N s, 1,4-tetrasubstituted-1,

ChemInform Abstract: Simultaneous C- and

ChemInform Abstract: Simultaneous C- and N-Alkylation of 2-Oxo-4,6-diaryl-1,2,3,4-tetrahydropyridine-3-carbonitrile under Solid—Liquid Phase-Transfer Conditions.

✍ Hetal C. Shah; Vaishali H. Shah; Nirmal D. Desai 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB 👁 1 views

ChemInform Abstract: Solid—Liquid Phase

ChemInform Abstract: Solid—Liquid Phase Transfer Catalytic Reaction of 1-Aminoanthraquinone with Alkyl Halides: A Case of N-Alkylation.

✍ Rajesh K. Sharma; M. M. Salunkhe 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

Modification of (1R,2S)-1,2-Diphenyl-2-a

Modification of (1R,2S)-1,2-Diphenyl-2-aminoethanol for the Highly Enantioselective, Asymmetric Alkylation of N-Diphenylphosphinoyl Arylimines with Dialkylzinc

✍ Hai-Le Zhang; Fan Jiang; Xiao-Mei Zhang; Xin Cui; Liu-Zhu Gong; Ai-Qiao Mi; Yao- 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 284 KB

## Abstract Experimental studies on the modification of (1__R__,2__S__)‐1,2‐diphenyl‐2‐aminoethanol, which is used to promote the alkylation of __N__‐diphenylphosphinoyl benzalimine with diethylzinc, revealed that __N__‐monosubstituted amino alcohols exhibited higher enantioselectivities than their

Structure and Hydrogen Bonding of Solid

Structure and Hydrogen Bonding of Solid N1-Alkyl-N2-arylthioureas. 13C CP/MAS, IR and Semi-Empirical AM1 Studies

✍ Iwona Wawer; Vera Koleva 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 434 KB 👁 2 views

Seven crystalline N'-alkyl-N2-arylthioureas were studied by I3C CP/MAS NMR and by IR spectroscopy. The double set of signals in I3C CP/MAS spectra indicates that molecules of N'-ethyl-Nz-(3-methy1phenyl)thiourea and N'-ethyl-N2-(4-methyIphenyl)thiourea are crystallographically non-equivalent. N'-Pro