✦ LIBER ✦
Parallel solid phase synthesis of tetrasubstituted diethylenetriamines via selective amide alkylation and exhaustive reduction of N-acylated dipeptides
✍ Scribed by Adel Nefzi; John M. Ostresh; Richard A. Houghten
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 441 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
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✦ Synopsis
Polyamines are a rapidly developing area of vital importance to biomedical science. Selective N-alkylation followed by N-terminal acylation and the complete reduction of carbonyl amide bonds enables the preparation by parallel solid phase synthesis of a wide range of N ~,N s, 1,4-tetrasubstituted-1,5-diamino-3-azapentane derivatives.