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Combinatorial chemistry using polymer-supported reagents

✍ Scribed by Stephen W Kaldor; Miles G Siegel


Book ID
104414989
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
478 KB
Volume
1
Category
Article
ISSN
1367-5931

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✦ Synopsis


During the past several years, the field of combinatorial chemistry has expanded to include not only solid- and solution-phase methods for expedited compound synthesis, but also hybrid approaches that span these two extremes. In particular, polymer-supported reagents have emerged as useful combinatorial chemistry tools for the discovery and optimization of new pharmaceutical leads.


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Clean sulfenylations are observed upon reaction of activated methylenes with phenyl succinimidyl sulfide. When working with diethyl benzylmalonate, the sulfenylated product can be selectively oxidized and thermally fragmented affording phenylsulfenic acid, initially, and diethyl benzylidenemalonate.