Combinatorial biocatalysis
β Scribed by Joseph O Rich; Peter C Michels; Yuri L Khmelnitsky
- Book ID
- 104414640
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 182 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1367-5931
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## Abstract A 39βmember library of bile acid derivatives was prepared starting from 3Ξ±,7Ξ±,12Ξ±βtrihydroxyβ5Ξ²βcholanβ24βoic acid methyl ester using a combinatorial biocatalytic approach. A regioselective oxidation step, catalyzed by hydroxysteroid dehydrogenases, followed by an acylation step with a
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