Combination therapy with bevacizumab and temsirolimus in squamous cell carcinoma of the head and neck
โ Scribed by Bhatt, Vijaya Raj; Ganti, Apar Kishor
- Book ID
- 122696402
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 201 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1368-8375
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## Abstract Head and neck cancer is a challenging disease that is expected to account for greater than 500,000 new cases worldwide in 2008. Toxicity has impeded advances in chemotherapy and radiation for head and neck cancer, and the prognosis for patients with recurrent and/or metastatic disease r
## Abstract ## Background: Activation of the mammalian target of rapamycin (mTOR) pathway in surgical margins of head and neck squamous cell carcinoma (HNSCC) is a predictor of recurrence and patients with minimal residual disease may benefit from adjuvant therapy with temsirolimus, an mTOR inhibi