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Combination of topotecan with cytarabine or etoposide in patients with refractory or relapsed acute myeloid leukemia: Results of a randomized phase I/II study

✍ Scribed by Norbert Vey; Hagop Kantarjian; Miloslav Beran; Susan O'Brien; Jorge Cortes; Charles Koller; Elihu Estey


Book ID
110233743
Publisher
Springer US
Year
1999
Tongue
English
Weight
67 KB
Volume
17
Category
Article
ISSN
0167-6997

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## Background: One potential mechanism of drug resistance to chemotherapy is the overexpression of multidrug resistance (mdr) genes coding for p-glycoprotein (p-gp), which leads to reduced intracellular retention of chemotherapy. this study tested the efficacy and toxicity of mitoxantrone, etoposid