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Combination of polymorphisms betweenMTHFRandTSgene modulates survival after 5-fluorouracil-based therapy in colorectal cancer patients

✍ Scribed by Jong Woo Kim; Jae Ho Lee; Seung Ho Hong; Dong Jin Yim; Hee Jung An; So Young Chong; Doyeun Oh; Nam Keun Kim


Book ID
107693528
Publisher
The Genetics Society of Korea
Year
2010
Tongue
English
Weight
325 KB
Volume
32
Category
Article
ISSN
1976-9571

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has