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Combination of high-performance liquid chromatography and SERS detection applied to the analysis of drugs in human blood and urine

✍ Scribed by Gerd Trachta; Bernd Schwarze; Bernd Sägmüller; Georg Brehm; Siegfried Schneider


Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
311 KB
Volume
693
Category
Article
ISSN
0022-2860

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## Abstract A simple, specific and sensitive HPLC method has been developed for the determination of metoprolol in human plasma and urine. Separation of metoprolol and atenolol (internal standard) was achieved on an Ace C~18~ column (5 μm, 250 mm×4.6 mm id) using fluorescence detection with λ~ex~=2