✦ LIBER ✦

Combination Chemotherapy in Histiocytosis X

✍ Scribed by Komp, Diane M. ;Vietti, Teresa J. ;Berry, D. H. ;Starling, Kenneth A. ;Haggard, Mary Ellen ;George, Stephen L.

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 333 KB
Volume: 3
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950030308

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Twenty‐five children with generalized histiocytosis X were treated with a combination of cyclophosphamide, vinblastine, and prednisone: 8 patients experienced complete response, 8 partial response, 2 improvement, and 7 no response. Response rates for children over 1 year of age were higher than those reported for single agents.

Twelve children are now off therapy with no evidence of disease for 10–50 months.

Very poor response rates and high toxicity were seen in children less than 1 year of age. The two infants who eventually achieved CR did so by other therapies.

Further trials in combination chemotherapy must weigh possible long‐term effects of such therapy against the prospect of more rapid disease control.

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