Malignant histiocytosis: Complete remission with combination chemotherapy

✍ Scribed by Richard S. Stein; Edgar M. Moran; Gerald E. Byrne Jr.

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 865 KB
• Volume: 38
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197609)38:3<1083::aid-cncr2820380307>3.0.co;2-b

✦ Synopsis

A case of a 16-year-old girl with malignant histiocytosis involving the lymph nodes, bone marrow, peripheral blood, liver, and spleen is described. This patient achieved a complete remission with cyclic quadruple chemotherapy consisting of cyclophosphamide, vincristine, procarbazine, and prednisone (COPP). She is alive and free of disease more than 4 years after the completion of COPP and after having had maintenance treatment with a small dose of cyclophosphamide for 2 3/4 years. Such good results with the COPP regimen in malignant histiocytosis have not been reported previously, and it is suggested that this modality of treatment warrants further trial.