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Colony inhibition studies on blocking and non-blocking serum effects on cellular immunity to moloney sarcomas

✍ Scribed by Ingegerd Hellström; Karl Erik Hellström

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
508 KB
Volume
5
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Moloney‐virus‐induced sarcomas, originating in BALB/c and A/Sn mice, were studied with the colony inhibition (CI) assay. Mice inoculated with the virus as adults developed tumors which spontaneously regressed (regressors) while mice inoculated with the same virus dose at an age of 21 days or less died from progressively growing tumors (progressors).

Serum from progressors blocked the colony inhibitory effect of lymph‐node cells (LNC) from the regressors. Serum from mice inoculated with the virus as adults had a similar blocking effect as long as the mice carried progressively growing tumors, but it did not block the LNC effect when harvested at the onset of regression or after its completion. When regressor sera were mixed with progressor sera the blocking effect of the latter decreased.

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Studies on serum-mediated inhibition of cellular immunity to spontaneous mouse mammary tumors
✍ G. H. Heppner 📂 Article 📅 1969 🏛 John Wiley and Sons 🌐 French ⚖ 554 KB

Sera from mice which have either spontaneously developed a mamniury tumor, or which have been immunized against such a tumor, have been shown capable of abrogating the ability of lymph-node cells from these mice to specifically inhibit colony formation by mammary tumor cells in vitro. Sera jrom mice