Inflammation in the intestine is a well-known risk factor for neoplastic changes in the mucosa. In fact, it has been shown that long-standing ulcerative colitis and colonic Crohn's disease have a significantly increased risk for developing colorectal cancer, although the estimates vary widely betwee
Colonic expression of leukotriene-pathway enzymes in inflammatory bowel diseases
β Scribed by James Jupp; Keith Hillier; Daniel H. Elliott; David R. Fine; Adrian C. Bateman; Penny A. Johnson; Angelica M. Cazaly; John F. Penrose; Anthony P. Sampson
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 359 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1078-0998
No coin nor oath required. For personal study only.
β¦ Synopsis
Background: Leukotrienes derived from the 5-lipoxygenase pathway are proinflammatory lipid mediators that possibly play a role in inflammatory bowel diseases. The expression of 5-lipoxygenase pathway proteins has not previously been examined in colonic mucosa in inflammatory bowel disease.
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