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Colloidal stability of polymeric nanoparticles in biological fluids

✍ Scribed by Stefano Lazzari, Davide Moscatelli, Fabio Codari, Mario Salmona, Massimo Morbidelli, Luisa Diomede


Book ID
113076639
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
403 KB
Volume
14
Category
Article
ISSN
1388-0764

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## Abstract The hydrolysis of diltiazem in biological fluids: whole blood, plasma, and gastric fluid was investigated under conditions considered close to the physiological situation. The most significant rate of hydrolytic degradation was found in whole blood (half‐life of 27h), followed by plasma