Stability of diltiazem in different biological fluids

✍ Scribed by Angus M. McLean; Eugenio A. Cefali; Jennifer S. Roden; Mario A. Gonzalez; Meir Bialer

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 430 KB
• Volume: 12
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510120502

✦ Synopsis

Abstract

The hydrolysis of diltiazem in biological fluids: whole blood, plasma, and gastric fluid was investigated under conditions considered close to the physiological situation. The most significant rate of hydrolytic degradation was found in whole blood (half‐life of 27h), followed by plasma (half‐life of 88h), while the least significant degradation rate was observed in gastric fluid (half‐life 153h). The kinetic profiles of diltiazem hydrolysis indicate that hydrolytic degradation in the biological fluids makes a minimal contribution to the clearance and disposition of the drug.