Cold-induced apoptosis of hepatocytes: mitochondrial permeability transition triggered by nonmitochondrial chelatable iron
โ Scribed by Ursula Rauen; Uta Kerkweg; Daniela Weisheit; Frank Petrat; Reiner Sustmann; Herbert de Groot
- Book ID
- 113629000
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 635 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0891-5849
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Acetaminophen overdose causes massive hepatic failure via mechanisms involving glutathione depletion, oxidative stress, and mitochondrial dysfunction. The ultimate target of acetaminophen causing cell death remains uncertain, and the role of apoptosis in acetaminophen-induced cell killing is still c
Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc