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Cognitive changes in asymptomatic carriers of the Huntington disease mutation gene

✍ Scribed by C. Verny; P. Allain; A. Prudean; M.-C. Malinge; B. Gohier; C. Scherer; D. Bonneau; F. Dubas; D. Le Gall


Book ID
111065321
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
98 KB
Volume
14
Category
Article
ISSN
1351-5101

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## Abstract Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion in the __IT‐15__ gene; however, it remains unknown how the mutation leads to selective neurodegeneration. Several lines of evidence suggest impaired mitochondrial f