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Cofactors in In Vitro Induction of Apoptosis in HL60 Cells by All-trans Retinoic Acid (ATRA)

✍ Scribed by Yves Carpentier; Philippe Mayer; Hélène Bobichon; Bernard Desoize


Book ID
119407406
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
655 KB
Volume
55
Category
Article
ISSN
0006-2952

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Acute promyelocytic leukemia (APL) is highly malignant and frequently expresses the PML-RAR␣ (promyelocytic leukemia-retinoic acid receptor-␣) fusion protein. This fusion protein is targeted by all-trans retinoic acid (ATRA) and arsenic trioxide (As 2 O 3 ), presently used in APL therapy. We have ev