𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Codon preference and primary sequence structure in protein-coding regions

✍ Scribed by Simon Tavaré; Brenda Song

Publisher
Springer
Year
1989
Tongue
English
Weight
926 KB
Volume
51
Category
Article
ISSN
1522-9602

No coin nor oath required. For personal study only.

✦ Synopsis

The stochastic complexity of a data base of 365 protein-coding regions is analysed. When the primary sequence is modeled as a spatially homogeneous Markov source, the fit to observed codon preference is very poor. The situation improves substantially when a non-homogeneous model is used. Some implications for the estimation of species phylogeny and substitution rates are discussed.

  1. Codon Usage. Since the pioneering work ofGrantham et al. (1980a; 1980b; 1981), it has been realized that DNA coding sequences do not use synonymous codons with equal frequency. A substantial amount of codon preference data

📜 SIMILAR VOLUMES

Homozygous deletions but no sequence mut
Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors
✍ Joan P. Packenham; Jack A. Taylor; Colleen H. Anna; Catherine M. White; Theodora 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 440 KB

## Abstract Chromosome 9p21 appears to harbor a tumor suppressor gene, as evidenced by deletions in this region in a variety of human primary tumors and cell lines. To map the deletion at 9p21 in bladder tumors, we analyzed DNA from 28 tumor and normal pairs at five microsatellite markers that flan

Protein sequence and gene structure for
Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence
✍ Jason Cyster; Chamorro Somoza; Nigel Killeen; Alan F. Williams 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 899 KB

## Abstract A partial cDNA clone for mouse leukosialin was isolated by use of a rat leukosialin cDNA probe. The mouse cDNA was then used to isolate genomic clones that corresponded to the two mouse genes detected in Southern blots. One gene encoded an open reading frame for the homologue of rat leu