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Codon modification of T cell receptors allows enhanced functional expression in transgenic human T cells

✍ Scribed by Kirsten B.J. Scholten; Duco Kramer; Esther W.M. Kueter; Marcus Graf; Thomas Schoedl; Chris J.L.M. Meijer; Marco W.J. Schreurs; Erik Hooijberg

Book ID
116366466
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
547 KB
Volume
119
Category
Article
ISSN
1090-2341

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In B cells the loci encoding immunoglobulin chains usually show allelic exclusion; a given B cell transcribes and translates only one productively rearranged allele of the heavy and light chain loci. This ensures that each B cell expresses only one antigen receptor. The loci encoding T-cell receptor