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Codon 72 polymorphism of the TP53 gene

✍ Scribed by Ara, S. (author);Lee, P. S.Y. (author);Hansen, M. F. (author);Saya, H. (author)

Book ID: 121384342
Publisher: Oxford University Press
Year: 1990
Tongue: English
Weight: 291 KB
Volume: 18
Category: Article
ISSN: 0305-1048
DOI: 10.1093/nar/18.16.4961

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✍ Ara, S. (author);Lee, P. S.Y. (author);Hansen, M. F. (author);Saya, H. (author) 📂 Article 📅 1990 🏛 Oxford University Press 🌐 English ⚖ 291 KB

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Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma

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This study was conducted to evaluate the frequency and prognostic impact of TP53 alterations stratified for the TP53 codon 72 polymorphism (c.215G4C, p.Arg72Pro) in a cohort of 109 patients with advanced ovarian carcinomas. TP53 sequence variants were observed in 80 of the 109 (73.4%) tumors and wer

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The original article to which this Erratum refers was published in Human Mutation 24: 21-34 (2004). Using a newly developed method-Arrayed Primer Extension (APEX) and direct sequencing of exon 10 and 11 to reanalyze for TP53 sequence alterations-13 new mutations were identified. In addition, a few