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Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma


Book ID
122839418
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
100 KB
Volume
13
Category
Article
ISSN
0169-5002

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The p p ! 6INK4 and p I8 genes are members of the gene famil coding for inhibitors of cyclin-dependent kinases 4 and 6. frequently deleted in many human neoplasms. To examine the role of these 3 genes in lung carcinogenesis, somatic mutations within the genes were analyzed by single-strand conformat