Cobalt-catalyzed annulation of aryl iodides with alkynes
β Scribed by Komeyama, Kimihiro; Kashihara, Tetsuya; Takaki, Ken
- Book ID
- 121080258
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- French
- Weight
- 732 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4039
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## Abstract A copperβcatalyzed crossβcoupling reaction of alkynes with aryl iodides is described. The system tolerates a broad range of functional groups and enables the use of sterically demanding substrates with only 1.0β2.5 molβ% of Cu~2~O and 1.0β2.5 molβ% of xantphos as the catalyst.
Synergic effect of iron and copper salts as catalysts for the Sonogashira-Hagihara cross-couplings of aryl iodides with terminal alkynes is demonstrated. High yields of cross-coupled products are obtained under conditions that are smoother than those using only CuI as catalyst. Furthermore no expens