prognosis in n case of lead poisoning are the ehnngcs whicli continued nbsorption will produce on t,hc liidneys nnd nrteries. Sir Tlioiniis l q g o lins stiitrtl tlint. t,lie ribsorpt,ion of h r o millig~~iniiics of Icnd pcr thy will producc lend poisoning.
Iu the nnremin of lend poisoning there is found n serious reduction in t.lie nunibor of blood cor~~usclcs i i i i i l t l i c qu:intity of hicmoglobin. 'l'h hone innrrow is tlic tissue froiii ~vhich thcsc rctl corpuscles are forincd, aiid it shows cvidencc of i~icrcnscd tict,ivity. A s n result of this nct,ivit.y, corpusclcs :ire fouiid in t,hc blood, which nre in nu iiii~nnturc slngc of dcr r l o ~~~i i ~n t , wliilst~ otlicrs, when stniiietl wit,li tippro-1wi:ite ilycs, show the prcsmcc of I)lric grnnrilcs. I his condition is Imo~rii iis " Imsophilc " tlegoiicrn-
iirc found in othcr coiitlitions bcsitlcs Ieiitl poisoniiig. 'l'liey :ire found, for csiimplc, after tjhc inhrilrition of ;I consitlc.mble qiinntity of turlicnliiic iiiitl in st:vcrc iiiiiemin.
Lend pnrolysis uenrly til\ruys iiffccts the iiriiis iintl usunlly the cstcnsor inusclcs of the forciirin niid hind. Y'liorc is dcgcneriitioii of tlic iiiotor nerves siipp1ying these muscles, nnd it is bcliovcil tliiit. llic motor cclls of the spin111 cord rilso iiiidcrgo :I ilcgencr.ntivc process. The result of this p:uxlysis is tlint the hand and fingers cannot be cstciitlctl iiiitl they reiiitiin in a codition of flesion--wrist tlrop.
Tlic estict* pntliology of lend colic is iiot knou-n. The siiiall intestine is often tlarker thriu iioriii~il, : i i i t l i t is believed that, tlic pniiiful intcstiniil coiitimtioii is due to the direct. effect of the letid, citlicr on tlic nerve cntlings or tlie musculnture of the gut mall.
J m i d eiicc~~litiloptitliy niiuiifcsts itsclf by couvulsioiis, delirium, u ~i c o ~~s c i o i ~s ~~c s s , :ud occgsionnllp by iicute mania. The trtigedies wliich accurrctl in the ciirly mnnufnctiirc of lend tctrnetliyl in Aniericii trertt clinrrrctcriscd hy :iciite uncoiitrolliiblc iunnia. Post xnortem examination rcvenlcd the prcsciicc i i i two ciises of 4.25 nnd 4 . 7 7 mg. of Icnd in the bruin. I,e:id eucephnlopnthy is nii estrcnicly rfirc occurrence in this country.
hlnrked nrterinl thickening is t,hc rcsult of lcntl :iI)sorption cont.inued over iniiiiy yews. 'l'his chiingc iiffccts. to some extent, .n11 tlic cirtcrics of thc botly, h i t iu particulnr tliosc of tlic Itidncy. 't'lic resultl of this is n slow, progrcssive friilurc of friiiotion. 'h ~i s i i : i l nitropioiis 1)rorliicts of bodily twtivity 110ciirnultitc owing to t,liis friilurc of csurat,ioii, rind lend it.sclf, \rliich circuiritcs in the blood st,rcjiiii, ~~r o b i i l ~l y :is ti pliospliute combined with protcin, iiccumul:it.cs too.
The Iridncy itsclf iiiidcygoes r i proccss of Iinrdcning or fibrosis. Albumcn is cscrctcd in t hc iirinc.
Tlic signs of reiinl ftiilurc progressively dcvclop.