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Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition

✍ Scribed by Siker Kimbung; Ewa Biskup; Ida Johansson; Kristina Aaltonen; Astrid Ottosson-Wadlund; Sofia Gruvberger-Saal; Heather Cunliffe; Bengt Fadeel; Niklas Loman; Pontus Berglund; Ingrid Hedenfalk

Book ID: 116335852
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 919 KB
Volume: 319
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2012.01.015

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## Abstract In addition to its mitogenic and survival actions, recent evidence indicates that IGF‐I can enhance DNA repair, implying IGF activity may limit the efficacy of many therapeutic strategies that rely on induction of DNA damage. Although the individual pathways by which DNA damage and IGF‐