Co-segregation of a gene encoding a deletion ligand for Tcrb-V3+T cells withMtv-3

✍ Scribed by Sue Fairchild; Andrew M. Knight; P. Julian Dyson; Kyuhei Tomonari

• Publisher: Springer-Verlag
• Year: 1991
• Tongue: English
• Weight: 361 KB
• Volume: 34
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00215257

✦ Synopsis

A gene encoding the endogenous superantigen Mlsc, which deletes Tcrb-V3+ T cells in the NOD inbred mouse strain, was found to co-segregate with Mtv-3 on chromosome 11. This identifies a fourth gene encoding a deletion ligand for Tcrb-V3+ T cells and extends recently published observations in support of the hypothesis that a number of endogenous superantigens are the products of Mtv proviruses.