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Co-ordinated isolation of CD8+ and CD4+ T cells recognizing a broad repertoire of cytomegalovirus pp65 and IE1 epitopes for highly specific adoptive immunotherapy

✍ Scribed by Zandvliet, Maarten L.; van Liempt, Ellis; Jedema, Inge; Veltrop-Duits, Louise A.; Willemze, Roel; Guchelaar, Henk-Jan; Falkenburg, J. H. Frederik; Meij, Pauline

Book ID
122167659
Publisher
Informa plc
Year
2010
Tongue
English
Weight
661 KB
Volume
12
Category
Article
ISSN
1465-3249

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Kinetics of cytomegalovirus (CMV) pp65 and IE-1-specific IFNγ CD8+ and CD4+ T cells during episodes of viral DNAemia in allogeneic stem cell transplant recipients: Potential implications for the management of active CMV infection
✍ Nuria Tormo; Carlos Solano; Isabel Benet; José Nieto; Rafael de la Cámara; Ana G 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB

## Abstract The dynamics of CMV pp65 and IE‐1‐specific IFNγ‐producing CD8^+^ (IFNγ CD8^+^) and CD4^+^ (IFNγ CD4^+^) T cells and CMV DNAemia were assessed in 19 pre‐emptively treated episodes of active CMV infection. Peripheral counts of IFNγ CD8^+^ and IFNγ CD4^+^ T cells inversely correlated with