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Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

✍ Scribed by Claudia B. Levy; Ana C. Stumbo; Ana P.D. Ano Bom; Elisabeth A. Portari; Yraima Carneiro; Jerson L. Silva; Claudia V. De Moura-Gallo

Book ID
116308020
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
665 KB
Volume
43
Category
Article
ISSN
1357-2725

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## Background: The p53 tumor suppressor gene encodes a nuclear phosphoprotein that is thought to be important to cell cycle regulation and dna repair and that also may regulate induction of apoptosis by ionizing radiation. somatic p53 gene mutations occur in 30-50% of breast carcinomas and are asso