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PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells

✍ Scribed by Debora Russo; Laura Ottaggio; Ilaria Penna; Giorgia Foggetti; Gilberto Fronza; Alberto Inga; Paola Menichini


Book ID
116300946
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
496 KB
Volume
402
Category
Article
ISSN
0006-291X

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P53 is a tumor suppressor protein critical for genome integrity. Although its control at the protein level is well known, the transcriptional regulation of the TP53 gene is still unclear. We have analyzed the organization of the TP53 gene domain using DNA arrays in several breast cancer and control