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Co-infection with Mycobacterium tuberculosis impairs HIV-specific CD8+ and CD4+ T cell functionality

✍ Scribed by S. Chetty; F. Porichis; P. Govender; J. Zupkosky; M. Pillay; B. Walker; T. Ndung’u; D. Kaufmann; V. Kasprowicz


Book ID
118452308
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
90 KB
Volume
16
Category
Article
ISSN
1201-9712

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## Abstract Th1 CD4^+^ T cells and their derived cytokines are crucial for protection against __Mycobacterium tuberculosis__. Using multiparametric flow cytometry, we have evaluated the distribution of seven distinct functional states (IFN‐γ/IL‐2/TNF‐α triple expressors, IFN‐γ/IL‐2, IFN‐γ/TNF‐α or